[Abstract Reproduced for Educational Purposes, emphasis mine]
Arch Sex Behav. 2008 Feb;37(1):85-99.
Sexual orientation in women with classical or non-classical congenital adrenal hyperplasia as a function of degree of prenatal androgen excess.
New York State Psychiatric Institute & Department of Psychiatry, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA. meyerb@childpsych.columbia.edu
Abstract
46,XX individuals with classical congenital adrenal hyperplasia (CAH) due to deficiency of the enzyme, 21-hydroxylase, show variable degrees of masculinization of body and behavior due to excess adrenal androgen production. Increased bisexuality and homosexuality have also been reported. This article provides a review of existing reports of the latter and presents a new study aimed at replicating the previous findings with detailed assessments of sexual orientation on relatively large samples, and at extending the investigation to the mildest form, non-classical (NC) CAH. Also, this is the first study to relate sexual orientation to the specific molecular genotypes of CAH. In the present study, 40 salt-wasters (SW), 21 SV (simple-virilizing), 82 NC, and 24 non-CAH control women (sisters and female cousins of CAH women) were blindly administered the Sexual Behavior Assessment Schedule (SEBAS-A, 1983 ed.; H. F. L. Meyer-Bahlburg & A. A. Ehrhardt, Privately printed). Most women were heterosexual, but the rates of bisexual and homosexual orientation were increased above controls not only in women with classical CAH, but also in NC women, and correlated with the degree of prenatal androgenization. Classifying women by molecular genotypes did not further increase the correlation. Diverse aspects of sexual orientation were highly intercorrelated, and principal components analysis yielded one general factor. Bisexual/homosexual orientation was (modestly) correlated with global measures of masculinization of non-sexual behavior and predicted independently by the degree of both prenatal androgenization and masculinization of childhood behavior. We conclude that the findings support a sexual-differentiation perspective involving prenatal androgens on the development of sexual orientation.
PMID: 18157628 [PubMed - indexed for MEDLINE]
In text now removed from her website, Dr. New offers treatment for fetuses in families "at risk" of having the dread anomaly, a lesbian daughter or even just a daughter who doesn't like dolls, want babies or to embody the gender stereotypical
I had an interesting discussion with my father, a retired academic physician, about Dr. New's work, my take on it, her take on homosexuality and my take on her take. My father is of the mind that clearly since CAH is correlated with homosexuality in women, it proves that homosexuality is a disorder that is potentially treatable and that Dr. New is just trying to treat. Make no mistake- CAH can be an extremely serious (especially in males) in its classical form. But as the Time magazine article states, many women are offered Dr. New's treatment (by other physicians) even when they don't know the gender of their fetus. What kind of scary crap shoot is that?
In its milder manifestations, I'm still considering the scoping problem of this concept of disordered behavior. Is wanting to do a conventionally man's job and not have children disordered? Why? Says who? Who got to be the arbiter of what was normal for a woman? Dr. New? Ayatollah Khameni? Pope Benedict? Me? (Talking about giving people a wide berth!) You?
Evolution is all about reproduction. In theory, anyway. [groan] ;) Genetic changes typically occur by mutation and selective pressure (meaning whether a particular mutation or variation is either more or less successful) usually determines whether or not a mutation will be passed on. Clearly you're less likely to reproduce if you are homosexual (although I know an awful lot of gays and lesbians who have had biological children...) so that would disfavor propagation of any "gay" genes. But I have still a lot of questions about when something ceases to be a disorder and just becomes a normal variation. I can go back to the blue eyes versus brown eyes business, for instance. Or light skin versus dark skin, or short versus tall, or any number of things that are genetic. I'm betting the first relatively tall, relatively white, blue-eyed human was probably considered aberrant in their culture of shorter, darker, brown eyed humans. Can selective pressure start to disfavor reproduction on an overcrowded planet, I wonder? Shades of Children of Men, for sure, right?
Anyway, from the perspective of the whole evolution and genetics argument, I look at all the gay and lesbian friends I've had and I could never pigeonhole them, saying they were all creative or all somehow gifted in other ways that made the reason for them to be here evolutionarily obvious to me. But what I can say, as the person who can always be counted upon to be fascinated by the new, the different, the foreign, the elusive, and to be more curious than threatened by people who are not just like me, is that I like them just as they are. I might want Brian to be more punctual or Bobby to have been less verbally caustic, but the very last thing I'd change about any of them would be their sexual orientation. If they don't care, I don't care. Maybe it's the perspective of a liberal, atheist, middle age person, but I really just don't think that who you're having sex with is that all important in the scheme of things, as long as it's consensual and you're kind to your partner.
Likewise, I really just don't think that whether a little girl plays with dolls and wants babies defines female normalcy.
* To be honest, I used to say I was a fundamentalist Buddhist. I was extremely tolerant of other peoples beliefs and ways of being because I figured sometimes it's so hard being here in the first place, I'd best not be judging how other people get by unless they do something very obviously (to me) immoral. (You know, cruelty to animals, abusing children, rape, murder, that kind of stuff). This drove my spouse to the edge of insanity. He thought I was way too tolerant, especially of cultures that end up using their beliefs to justify abuse of women. (Though I already had plenty of bad words to say about things like honor killings, child marriage, female circumcision, purdah and such.) I just... tried to accept that other people had the right to do things another way, or differently. Now, in my pre-50's dotage, I've decided he's totally spot on. A bit of Ayaan Hirsi Ali, some Mukhtar Mai, a dash of Somaly Mam and Nujood Ali, and even just reflecting on the fact that I was raised in a pro-civil rights home in Georgia and Florida in the 1960's, and hey, basic decency to living creatures trumps human rights, women's rights, and civil rights. Because it comprises all of them.
I know my Won Buddhist teacher would say it's definitely sattva to say that, maybe just maybe, people ought to be more tolerant. Step back and realize that so few of other people's personal choices really affect us or our own choices. With a nod in his direction, I honor him, his principles and the remembrance of the hardest concept I've ever (including superposition and the particle/wavelike duality) pondered.
Detached Compassion, if you're interested.
Maybe all these people who think that females should all be girly girls should give it a spin?
When they're not busy being in awe of what all these uppity women out there are doing or have done, that is.
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